ABSTRACT
Objectives: To study the changes of blood levels of soluble semaphorin 4D (sSema4D) and matrix metalloproteinases-14 (MMP-14);to explore the correlation between sSema4D and ventricular remodeling in patients of dilated cardiomyopathy with chronic heart failure. Methods: Our research included in 2 groups:Dilated cardiomyopathy group, n=86 patients and Control group, n=32 healthy subjects. Blood levels of sSema4D, MMP14, Pro-BNP and hs-CRP were examined by ELISA. Left atrial diameter (LAD), right ventricular diameter (RVD), ejection fraction (EF), left ventricular end diastolic diameter (LVEDD), left ventricular fractional shortening (LVFS) were measured by echocardiography. Correlation analysis between blood levels of sSema4D, MMP-14 and the parameters for left ventricular remodeling was conducted. Results: Blood levels of sSema4D and MMP14 were different between 2 groups, P Conclusion: Serum level of sSema4D might be related to ventricular remodeling in patients with dilated cardiomyopathy which could be used as risk factor for predicting the prognosis of heart failure in relevant patients.
ABSTRACT
Objective:To assess the efficacy and safety of Zyrtec drops which is a patent product of UCBpharma in treatment of allergy rhinitis in children. Method :A total of 47 children of both sexes aged between 2 to6 years with allergy rhinitis (AR) were included in this study,who were randomly selected to be treated withZyrtec (Cetirizine 2 HCL) drops 5 mg daily for 3 weeks. Investigators made a global evaluation with symptomscores before treatment and once a week for 3 weeks after treatment. Result:An improvement was shown in eachweek after treatment with statistical significance (P＜0.01). Zyrtec drops provided an excellent improvement atthe end of the study. Tolerance was good. Conclusion :For acting fast ,potent ,good tolerance and convenience inuse,Zyrtec drops is a better treatment in AR in kids.